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β-CGRP(human)(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
β-CGRP(human)(trifluoroacetate salt)图片
规格:98%
分子量:3793.4
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
β-Calcitonin gene-related peptide (β-CGRP) is a neuropeptide with roles in vasodilation, cardiovascular regulation, and inflammation.
货号:ajcx19100
CAS:N/A
分子式:C162H267N51O48S3?XCF3COOH
分子量:3793.4
溶解度:Water: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

β-Calcitonin gene-related peptide (β-CGRP) is a neuropeptide with roles in vasodilation, cardiovascular regulation, and inflammation. It belongs to the calcitonin family of peptides, which also includes α-CGRP , amylin , calcitonin , and adrenomedullin. β-CGRP binds selectively to a heteromeric complex of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1; IC50 = 0.01 nM) over a complex of CLCR and RAMP2 (IC50 = 300 nM). It binds to rat brain and spleen membrane preparations (IC50s = 1.1 and 1 nM, respectively) and relaxes human cerebral and middle meningeal arterial segments precontracted with prostaglandin F2α . In vivo, β-CGRP induces a 50% increase in diameter of arterioles precontracted with human endothelin-1 in hamster cheek pouch at a concentration of 15.8 pM.