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5-Amino-6-(D-ribitylamino)uracil(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5-Amino-6-(D-ribitylamino)uracil(hydrochloride)图片
规格:98%
分子量:349.2
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
C9H16N4O6.2HCl
货号:ajcx19264
CAS:134452-11-2
分子式:C9H16N4O6.2HCl
分子量:349.2
溶解度:DMSO: Slightly Soluble,Water: Slightly Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

5-Amino-6-(D-ribitylamino)uracil (5-A-RU) is a derivative of uracil and a precursor to riboflavin.1,2 It reacts non-enzymatically with dihydroxy acetone, methylglyoxal, or glyoxal to activate mucosal-associated invariant T (MAIT) cells isolated from iVα19-Tg and iVα19Vβ6-DTg mice.2 5-A-RU (100 nM, i.p.), when administered in combination with methylglyoxal, activates MAIT cells in iVα19 Cα-/--Tg mice. It is also a substrate for F0 synthase, an enzyme involved in the biosynthesis of the energy metabolism cofactor F420 in archaea, bacteria, and eukaryotes.1

参考文献
1. Decamps, L., Philmus, B., Benjdia, A., et al. Biosynthesis of F0, precursor of the F420 cofactor, requires a unique two radical-SAM domain enzyme and tyrosine as substrate. J. Am. Chem. Soc. 134(44), 18173-18176 (2012).
2. Soudais, C., Samassa, F., Sarkis, M., et al. In vitro and in vivo analysis of the gram-negative bacteria-derived riboflavin precursor derivatives activating mouse MAIT cells. J. Immunol. 194(10), 4641-4649 (2015).