A neuropeptide with diverse biological activities
货号:ajcx22416
CAS:N/A
分子式:C20H25D9O5
分子量：363.5
溶解度:DMF: >100 mg/ml,DMSO: >100 mg/ml,Ethanol: >100 mg/ml,PBS (pH 7.2): 3 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ent-8-iso-Prostaglandin F_2α-d₉(ent-8-iso-PGF_2α-d₉) contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19',20,20, and positions. It is intended for use as an internal standard for the quantification of ent-8-iso-PGF_2αby GC-or LC-mass spectrometry. Isoprostanes are produced by the non-enzymatic, free-radical peroxidation of arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have a potent biological activity. ent-8-isoProstaglandin F_2α(ent-8-isoPGF_2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC₅₀values of 31 and 54 nM, respectively.¹

1.Hou, X., Robers, L.J., II, Gobeil, F., Jr., et al.Isomer-specific contractile effects of a series of synthetic F2-isoprostanes on retinal and cerebral microvasculatureFree Radical Biology & Medicine36(2)163-172(2004)