An excitatory neurotransmitter
货号:ajcx22822
CAS:7558-63-6
分子式:C5H9NO4.NH3
分子量：164.2
溶解度:PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

L-Glutamic acid is a non-essential amino acid and the primary excitatory neurotransmitter in the CNS.¹It acts on ionotropic and metabotropic receptors to induce excitatory synaptic transmission and has roles in synaptic plasticity. Excessive release of L-glutamic acid induces excitotoxicity that is associated with various human diseases, including amyotrophic lateral sclerosis (ALS), stroke, Parkinson's disease, Alzheimer's disease, and Huntington's disease.²Excessive L-glutamic acid release, in its protonated glutamate form, also occurs during seizure activity and contributes to epileptogenesis and seizure-induced brain damage.³

1.Garattini, S.Glutamic acid, twenty years laterJ. Nutr.130(4S Suppl)901S-909S(2000) 2.Greenamyre, J.T.The role of glutamate in neurotransmission and in neurologic diseaseArch. Neurol.43(10)1058-1063(1986) 3.Barker-Haliski, M., and White, H.S.Glutamatergic mechanisms associated with seizures and epilepsyCold Spring Harb. Perspect. Med.5(8)a022863(2015)