An internal standard for the quantification of prostaglandin D2
货号:ajcx23328
CAS:211105-29-2
分子式:C20H28D4O5
分子量：356.5
溶解度:DMF: >100 mg/ml (from PGD2),DMSO: >50 mg/ml (from PGD2),Ethanol: >75 mg/ml (from PGD2),PBS pH 7.2: >5 mg/ml (from PGD2)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Prostaglandin D₂-d₄(PGD₂-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGD₂by GC-or LC-mass spectrometry. PGD₂is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD₂, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD₂is also produced in the brainviaan alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace.2,3 In the brain, PGD₂produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD₂inhibits human ovarian tumor cell proliferation with an IC₅₀of 6.8 µM.

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