An internal standard for the quantification of indoxyl sulfate
货号:ajcx25542
CAS:1644451-34-2
分子式:C8HD5NO4S·K
分子量：256.3
溶解度:DMSO: slightly soluble,Methanol: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Indoxyl sulfate-d₅is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan .¹It is formedviasulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver.^2,1Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC₅₀= 12.1 nM in a reporter assay).³It also inhibits the organic anion transporter (OAT) isoforms OAT1 and OAT3 (K_is = 34.2 and 74.4 µM, respectively for the rat transporters) in S2 proximal tubule cells.⁴Indoxyl sulfate (0.2 and 1 mM) increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells.⁵It increases serum creatinine and blood urea nitrogen (BUN) levels in the 5/6 nephrectomized rat model of chronic renal failure when administered at a dose of 50 mg/kg.⁴

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