An internal standard for the quantification of (±)-ibuprofen
货号:ajcx25980
CAS:1219805-09-0
分子式:C13H14D3O2 • Na
分子量：231.3
溶解度:DMF: 30 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 2 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(±)-Ibuprofen-d₃is intended for use as an internal standard for the quantification of (±)-ibuprofen by GC- or LC-MS. (±)-Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and non-selective COX inhibitor (IC₅₀s = 2.6 and 1.3 µM for human recombinant COX-1 and COX-2, respectively).¹In vivo, (±)-ibuprofen inhibits late-phase formalin-induced paw licking in mice (ED₅₀= 6.1 mg/kg).²It also inhibits acetic acid-induced writhing in mice (ED₅₀= 0.47 mg/kg). Formulations containing (±)-ibuprofen have been used in the treatment of fever and mild to severe pain.

1.Johnson, J.L., Wimsatt, J., Buckel, S.D., et al.Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledonsArch. Biochem. Biophys.324(1)26-34(1995) 2.Seguin, L., Le Marouille-Girardon, S., and Millan, M.J.Antinociceptive profiles of non-peptidergic neurokinin1 and neurokinin2 receptor antagonists: A comparison to other classes of antinociceptive agentPain61(2)325-343(1995)