Angolinehydrochloride是一种有效的选择性的IL6/STAT3信号通路抑制剂，IC50为11.56μM。Angolinehydrochloride抑制STAT3磷酸化及其靶基因表达，并抑制癌细胞增殖。
货号:ajcx30166
CAS:1071676-04-4
分子式:C22H22ClNO5
分子量：415.87
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].

[1]. Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.