R18TFA是14-3-3的肽拮抗剂，其KD值为70-90nM。R18可有效阻断14-3-3与其配体Raf-1激酶的结合，可有效地消除14-3-3对磷酸酶诱导的Raf-1失活的保护作用。
货号:ajcx32086
CAS:N/A
分子式:C103H158F3N27O31S3
分子量：2423.73
溶解度:H2O :< 0.1 mg/mL (ultrasonic) (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

R18 TFA is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1[1].

[1]. B Wang, et al. Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry. 1999 Sep 21;38(38):12499-504.