2′-Deoxy-2′-fluoroadenosine可用于合成可与RNA杂交的2'-脱氧-2'-氟修饰的寡核苷酸。2′-Deoxy-2′-fluoroadenosine能被大肠杆菌嘌呤核苷磷酸化酶(PNP)有效地裂解成毒性物2-氟腺嘌呤(FAde)。2′-Deoxy-2′-fluoroadenosine对表达大肠杆菌PNP的肿瘤表现出良好的体内活性。
货号:ajcx32216
CAS:64183-27-3
分子式:C10H12FN5O3
分子量：269.23
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP[1].

[1]. A E Hassan, et al. A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy. Nucleosides Nucleotides Nucleic Acids. 2000 Mar;19(3):559-65.