Cetraxate hydrochloride (DV-1006) 是一种具有粘膜保护作用的，具有口服活性的抗溃疡试剂 (anti-ulcer)，可用于胃溃疡研究。Cetraxate hydrochloride 是一种有效的顶体蛋白酶 (acrosomal proteinase acrosin) 抑制剂，Ki 和 IC50 分别为 0.94 μM 和 3.3 μM。
货号:ajcx33202
CAS:27724-96-5
分子式:C17H24ClNO4
分子量：341.83
溶解度:DMSO : 83.33 mg/mL (243.78 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Cetraxate hydrochloride (DV-1006), an orally active anti-ulcer agent with mucosal protective effects, can be used for gastric ulcers research[1]. Cetraxate hydrochloride is a potent acrosomal proteinase acrosin inhibitor with a Ki and an IC50 of 0.94 μM and 3.3 μM, respectively[2].

[1]. Fumihiko Katagiri, et al. Cetraxate raises levels of calcitonin gene-related peptide and substance P in human plasma. J Pharm Pharmacol. 2004 Apr;56(4):557-61.
[2]. H Sumi, et al. Inhibitors of the acrosomal proteinase acrosin: human urinary trypsin inhibitor (UTI) and 4-(2-carboxyethyl) phenyl trans 4-aminomethylcyclohexanecarboxylate hydrochloride (DV-1006). Experientia. 1980 Sep 15;36(9):1103-4.