您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > SJF620 hydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
SJF620 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SJF620 hydrochloride图片
规格:98%
分子量:797.3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
SJF620 hydrochloride 是一种 PROTAC BTK 降解剂,DC50 为 7.9 nM。SJF620 含有 Lenalidomide 类似物,可募集 CRBN。
货号:ajcx34072
CAS:N/A
分子式:C41H45ClN8O7
分子量:797.3
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

SJF620 hydrochloride is a potent PROTAC BTK degrader with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN[1].

SJF620 hydrochloride is a PROTAC that retains potent degradation of BTK in cellular assays with a DC50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA[1].

SJF620 hydrochloride has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with the half life (t1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802[1].

[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.