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Donepezil-d7 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Donepezil-d7 hydrochloride图片
规格:98%
分子量:423
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Donepezil-d7 (hydrochloride) (E2020-d7) 是 Donepezil 的氘代物。Donepezil (E2020 free base) 是 AChE 抑制剂,对牛 AChE 和人 AChE 的 IC50 分别为 8.12 nM 和 11.6 nM。
货号:ajcx35478
CAS:1261394-20-0
分子式:C24H23D7ClNO3
分子量:423
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Donepezil-d7 (hydrochloride) (E2020-d7) is the deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13.;Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999. 38(1): p. 181-93.;Huang, Z.H., et al., Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury. CNS Neurosci Ther, 2012. 18(2): p. 185-7.