JAK-IN-14 是一种有效和选择性的 JAK1 抑制剂，IC50 值小于5μM。JAK-IN-14 对 JAK1 的选择性是 JAK2 和 JAK3 的 >8倍 (专利WO201611970A1，化合物16).
货号:ajcx35700
CAS:1973485-06-1
分子式:C19H15FN4O
分子量：334.35
溶解度:DMSO : 10.5 mg/mL (31.40 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

JAK-IN-14 is a potent and selective JAK1 inhibitor, with an IC50 of 8-fold more selective for JAK1 than JAK2 and JAK3 (Patent WO2016119700A1, compound 16)[1].

[1]. Jin Li, et al. Substituted imidazo [1, 2-a] pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof. WO2016119700A1.