(R)-NVS-ZP7-4 是 NVS-ZP7-4 的 R 型异构体。 NVS-ZP7-4 是一种锌转运体 SLC39A7 (ZIP7)的抑制剂，也是第一个报道的能探测内质网锌水平影响的化学分子，研究 ZIP7 作为 Notch 通路中的一种新的药物节点。
货号:ajcx15224
CAS:N/A
分子式:C28H28FN5OS
分子量：501.62
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(R)-NVS-ZP7-4 is the R-isomer of NVS-ZP7-4. NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.

[1]. Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15(2):179-188.