| 包装: | 1mg |
| 规格: | 98% |
| 市场价: | 3689元 |
| 分子量: | 3037.4 |
Background:
ω-Conotoxin GVIA is a peptide originally isolated from the marine mollusk C. geographus that acts as an N-type calcium channel blocker. It binds to human neocortical, rat hippocampal, and chick brain synaptic plasma membranes (IC50s = 4.6, 60, and 150 pM, respectively, in radioligand binding assays). ω-Conotoxin GVIA inhibits norepinephrine and acetylcholine release from human neocortical slices (IC50s = 14 and 3 nM, respectively) and calcium influx into chick synaptosomes by 92% when used at a concentration of 0.1 μM. It blocks electrically-evoked twitch responses of rat vas deferens and guinea pig ileum (IC50s = 9.8 and 55 nM, respectively) but does not affect the postjunctional contractile responses induced by norepinephrine on vas deferens or by carbamoylcholine on ileum. ω-Conotoxin GVIA does not affect potassium-induced contraction of rat aorta at concentrations up to 1 μM.
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