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Histone H3K14Ac/H3K23Ac(1-24)-GGK-biotin(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Histone H3K14Ac/H3K23Ac(1-24)-GGK-biotin(trifluoroacetate salt)图片
包装:250ug
规格:98%
市场价:2918元
分子量:3107.6

产品介绍
C131H232N46O39S.XCF3COOH
货号:ajcx19464
CAS:N/A
分子式:C131H232N46O39S.XCF3COOH
分子量:3107.6
溶解度:Water: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Histone H3K14Ac/H3K23Ac (1-24)-GGK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 2-25 of the human histone H3 sequence. It is acetylated at lysine 14 and lysine 23 and biotinylated via a C-terminal GGK linker. Acetylation of H3K14 or H3K23 is associated with transcriptional activation and H3K14 acetylation is required for trimethylation of H3K4.1,2 H3K23 acetylation is decreased in wild-type but increased in uninephrectomized db/db mouse kidney.3

参考文献
1. Keating, S.T., van Diepen, J.A., Risken, N.P., et al. Epigenetics in diabetic nephropathy, immunity and metabolism. Diabetologia 61(1), 6-20 (2018).
2. Nakanishi, S., Sanderson, B.W., Delventhal, K.M., et al. A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation. Nat. Struct. Mol. Biol. 15(8), 881-888 (2008).
3. Sayyed, S.G., Gaikwad, A.B., Lichtnekert, J., et al. Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10. Nephrol. Dial. Transplant. 25(6), 1811-1817 (2010).