| 规格: | 98% |
| 分子量: | 306.3 |
| 包装 | 价格(元) |
| 500ug | 电议 |
| 1mg | 电议 |
Background:
Hesperetin-13C-d3 is intended for use as an internal standard for the quantification of hesperetin by GC- or LC-MS. Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol.1 Hesperetin reduces the transcription of ACAT2 mRNA in HepG2 cells and reduces ApoB protein synthesis in a dose-dependent manner. The EC50 for these responses is approximately 50 μM. Hesperetin also inhibits histamine release from IgE-challenged RBL-2H3 cells, with a potency comparable to the antihistamine azelastine .2
|1. Wilcox, L.J., Borradaile, N.M., de Dreu, L.E., et al. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J. Lipid Res. 42(5), 725-734 (2001).|2. Lee, N.K., Choi, S.H., Park, S.H., et al. Antiallergic activity of hesperidin is activated by intestinal microflora. Pharmacology 71(4), 174-180 (2004).
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