A neuropeptide with diverse biological activities
货号:ajcx20890
CAS:N/A
分子式:C27H35D3N2O4.HCl
分子量：494.1
溶解度:DMF: 15 mg/mL,DMSO: 10 mg/mL,Ethanol: 10 mg/mL,PBS (pH 7.2): 0.25 mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(±)-Verapamil-d₃(hydrochloride) is intended for use as an internal standard for the quantification of verapamil by GC- or LC-MS. Verapamil is the prototypical blocker of L-type calcium channels that produces excitation-contraction uncoupling in cardiac muscle by preventing the slow-inward current of calcium ions.¹Verapamil can also block calcium fluxes in vascular smooth muscle. It has both peripheral and coronary vasodilator effects (IC₅₀= 0.38 μM in guinea pig aortic strip) and has been used to control hypertension, angina, cardiac arrhythmia, and vascular headaches.^2,3,4Verapamil has also been used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell lines.⁵

1.Singh, B.N.The mechanism of action of calcium antagonists relative to their clinical applicationsBr. J. Clin. Pharmacol.21109S-121S(1986) 2.Dei, S., Romanelli, M.N., Scapecchi, S., et al.Verapamil analogues with restricted molecular flexibility: Synthesis and pharmacological evaluation of the four isomers of α-[1-[3-[N-[1-[2-(3,4-dimethoxy-phenyl)ethyl]]-N-methylamino]cyclohexyl]]-α-isopropyl-3,4-dimethoxybenzene-acetonitrileJournal of Medicinal Chemistry36439-445(1993) 3.Dawson, J.R., Whitaker, N.H.G., and Sutton, G.C.Calcium antagonist drugs in chronic stable angina. Comparison of verapamil and nifedipineBritish Heart Journal46508-512(2013) 4.Campbell, T.J., and Williams, K.M.Therapeutic drug monitoring: Antiarrhythmic drugsBr. J. Clin. Pharmacol.52307-319(1998) 5.Rabindran, S.K., He, H., Singh, M., et al.Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin CCancer Res.58(24)5850-5858(1998)