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(S)-Pramipexole-d5(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(S)-Pramipexole-d5(hydrochloride)图片
包装:1mg
规格:98%
市场价:3541元
分子量:289.3

产品介绍
An internal standard for the quantification of (S)-pramipexole
货号:ajcx20966
CAS:1217601-58-5
分子式:C10H12D5N3S.2HCl
分子量:289.3
溶解度:Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

(S)-Pramipexole-d5is intended for use as an internal standard for the quantification of (S)-pramipexole by GC- or LC-MS. (S)-Pramipexole is a dopamine D2S, D2L, D3, and D4receptor agonist (EC50s = 426.58, 338.84, 2.24, and 128.82 nM, respectively, in a [35S]GTPγS binding assay).1It is also a partial agonist of α2A-adrenergic receptors (α2A-ARs; EC50= 3,548.13 nM). (S)-Pramipexole is selective for dopamine D2-4receptors (Kis = 954.99, 1,698.24, 12.59, 128.82 nM for D2S, D2L, D3, and D4receptors, respectively, in a radioligand binding assay) over D1and D5receptors (Kis = >10,000 nM for both).2It prevents MPTP-induced decreases in the number of dopaminergic neurons in the substantia nigra pars compacta in common marmosets when administered at a dose of 60 μg/kg per day before, during, and after administration of MPTP.3Formulations containing (S)-pramipexole have been used in the treatment of Parkinson's disease and restless legs syndrome.


1.Newman-Tancredi, A., Cussac, D., Audinot, V., et al.Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D2-like receptor and α1/α2-adrenoceptorJ. Pharmacol. Exp. Ther.303(2)805-814(2002) 2.Millan, M.J., Maiofiss, L., Cussac, D., et al.Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypesJ. Pharmacol. Exp. Ther.303(2)791-804(2002) 3.Iravani, M.M., Haddon, C.O., Cooper, J.M., et al.Pramipexole protects against MPTP toxicity in non-human primatesJ. Neurochem.96(5)1315-1321(2006)