A neuropeptide with diverse biological activities
货号:ajcx21476
CAS:N/A
分子式:C12H16N6O4.XH2O
分子量：308.3
溶解度:DMF: 25 mg/ml,DMSO: 14 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

5'-N-Ethylcarboxamidoadenosine (NECA) is an adenosine analog that acts as an agonist of adenosine receptors (K_is = 1,880, 6,660, and 3.5 nM for human adenosine subtypes A₁, A_2A, and A₃, respectively).¹NECA is reported to act as a potent vasodilator and can inhibit platelet aggregation by increasing cAMP (EC₅₀= 3.1 µM).^2,3

1.Volpini, R., Dal ben, D., Lambertucci, C., et al.N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptorJ. Med. Chem.50(6)1222-1230(2007) 2.de Zwart, M., Link, R., von Frijtag Drabbe KÜnzel, J.K., et al.A functional screening of adenosine analogues at the adenosine A2B receptor: a search for potent agonistsNucleosides Nucleotides17(6)969-985(1998) 3.Cusack, N.J., and Hourani, S.M.O.5'-N-ethylcarboxamidoadenosine: A potent inhibitor of human platelet aggregationBr. J. Pharmacol.72(3)443-447(1981)