规格: | 98% |
分子量: | 376.6 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Background:
Alloisolithocholic acid (AILCA) is an allomonohydroxy bile acid.[1],[2] It activates large-conductance calcium-activated potassium channels (BKCas; EC50 = 44.21 µM in Xenopus oocytes expressing human channels).[1] AILCA (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.[2]
参考文献:
[1].Bukiya, A.N., McMillan, J., Parrill, A.L., et al.Structural determinants of monohydroxylated bile acids to activate β1 subunit-containing BK channelsJ. Lipid Res.49(11)2441-2451(2008)
[2].Vonk, R.J., Tuchweber, B., Massé, D., et al.Intrahepatic cholestasis induced by allo monohydroxy bile acid in ratsGastroenterology80(2)242-249(1981)