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Alloisolithocholic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alloisolithocholic Acid图片
规格:98%
分子量:376.6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
An allomonohydroxy bile acid
货号:ajcx21644
CAS:2276-93-9
分子式:C24H40O3
分子量:376.6
溶解度:DMF: 1mg/mL,DMF:PBS (pH 7.2) (1:3): 0.25mg/mL
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Alloisolithocholic acid (AILCA) is an allomonohydroxy bile acid.[1],[2] It activates large-conductance calcium-activated potassium channels (BKCas; EC50 = 44.21 &#181M in Xenopus oocytes expressing human channels).[1] AILCA (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.[2]

参考文献:
[1].Bukiya, A.N., McMillan, J., Parrill, A.L., et al.Structural determinants of monohydroxylated bile acids to activate β1 subunit-containing BK channelsJ. Lipid Res.49(11)2441-2451(2008)
[2].Vonk, R.J., Tuchweber, B., Massé, D., et al.Intrahepatic cholestasis induced by allo monohydroxy bile acid in ratsGastroenterology80(2)242-249(1981)