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Chenodeoxycholic Acid-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Chenodeoxycholic Acid-d4图片
规格:98%
分子量:396.6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
货号:ajcx22064
CAS:99102-69-9
分子式:C24H36D4O4
分子量:396.6
溶解度:DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Chenodeoxycholic acid-d4(CDCA-d4) is intended for use as an internal standard for the quantification of CDCA by GC- or LC-MS. CDCA is a hydrophobic primary bile acid.1It is formed from cholesterol in the liverviaa multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. CDCA is a farnesoid X receptor (FXR) agonist that binds to FXRs in a TR-FRET assay (EC50= 13 µM) and induces FXR transactivation in a reporter assay.2,3It induces transcription of the gene encoding the Nrf2 target glutamate cysteine ligase (GCL) in primary hepatocytes and HepG2 cells when used at concentrations ranging from 25 to 100 µM.4


1.Fiorucci, S., and Distrutti, E.Chenodeoxycholic acid: An update on its therapeutic applicationsBile acids and their receptors. Handbook of experimental pharmacology256265-282(2019) 2.Ohinata, Y., Payer, B., O'Carroll, D., et al.Blimp1 is a critical determinant of the germ cell lineage in miceNature436207-213(2005) 3.Urizar, N.L., Liverman, A.B., Dodds, D.T., et al.A natural product that lowers cholesterol as an anatagonist ligand for FXRScience296(5573)1703-1706(2002) 4.Tan, K.P., Yang, M., and Ito, S.Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stressMol. Pharmacol.72(5)1380-1390(2007)