CU-115 是一种有效的 TLR8 拮抗剂 (IC50=1.04 μM)，对 TLR8 的选择性优于 TLR7 (IC50=>50 μM)。
货号:ajcx22142
CAS:2471982-20-2
分子式:C21H11F7INO2
分子量：569.2
溶解度:DMF: 10mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:5): 0.15mg/mL,Ethanol: 0.25mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CU-115 is a toll-like receptor 8 (TLR8) antagonist (IC₅₀= 1.04 µM).¹It is selective for TLR8 over TLR7 (IC₅₀= >50 µM). CU-115 inhibits increases in type I IFN transcriptional activity induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD in a luciferase reporter assay when used at concentrations of 5 and 20 µM. It decreases TNF-α and IL-1β production induced by R-848 in THP-1 cells when used at a concentration of 5 µM.

1.Padilla-Salinas, R., Anderson, R., Sakaniwa, K., et al.Discovery of novel small molecule dual inhibitors targeting toll-like receptors 7 and 8J. Med. Chem.62(22)10221-10244(2019)