A neuropeptide with diverse biological activities
货号:ajcx22568
CAS:N/A
分子式:C24H30D4N4O5S
分子量：494.6
溶解度:DMF: 10 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 3 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Glimepiride-d₄is intended for use as an internal standard for the quantification of glimepiride by GC- or LC-MS. Glimepiride is a long-acting sulfonylurea that inhibits ATP-sensitive potassium (K_ATP) channels in pancreatic β-cells (IC₅₀= 3 nM), which leads to the release of insulin.¹At 20 μM, glimepiride has been shown to increase the activity of intracellular insulin receptors and to prevent insulin receptor downregulation during chronic insulin stimulation through a mechanism involving protein kinase C activation.²It has been reported to be less effective at inhibiting nonpancreatic K_ATPchannels, and therefore contributes fewer cardiac actions, compared to earlier generations of sulfonylurea anti-type 2 diabetes treatments.³

1.Song, D.K., and Ashcroft, F.M.Glimepiride block of cloned β-cell, cardiac and smooth muscle KATP channelsBr. J. Pharmacol.133(1)193-199(2001) 2.Hribal, M.L., D'Alfonso, R., Giovannone, B., et al.The sulfonylurea glimepiride regulates intracellular routing of the insulin-receptor complexes through their interaction with specific protein kinase C isoformsMol. Pharmacol.59(2)322-330(2001) 3.Mocanu, M.M., Maddock, H.L., Baxter, G.F., et al.Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxideCirculation103(25)3111-3116(2001)