A PARP inhibitor
货号:ajcx22974
CAS:5813-86-5
分子式:C8H9NO2
分子量：151.2
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml,Ethanol: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

m-Methoxybenzamide is an inhibitor of poly(ADP-ribose) polymerase (PARP; K_i=<2 µm).¹It also inhibits human placental ADP ribosyl transferase activity by 93% when used at a concentration of 100 µM.²m-Methoxybenzamide (100, 200, and 300 mg/kg) increases the pain threshold in the paw pinch test in rats.³

1.Purnell, M.R., and Whish, W.J.Novel inhibitors of poly(ADP-ribose) synthetaseBiochem. J.185(3)775-777(1980) 2.Burtscher, H.J., Auer, B., Klocker, H., et al.Isolation of ADP-ribosyltransferase by affinity chromatographyAnal. Biochem.152(2)285-290(1986) 3.Sanders, R., Dill, R.E., Dorris, R.L., et al.Analgesic effects of 3-methoxybenzamide in ratsJ. Pharm. Pharmacol.41(4)268-269(1989)