A fungal metabolite with potassium channel inhibitory and antiviral activities
货号:ajcx23054
CAS:145603-76-5
分子式:C30H44O5
分子量：484.7
溶解度:Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Nalanthalide is a diterpenoid pyrone fungal metabolite that has been found inNalanthamalaand has potassium channel inhibitory and antiviral activities.¹It inhibits binding of the potassium channel inhibitor charybdotoxin to Jurkat cell membranes (IC₅₀= 3 µM) and inhibits rubidium efflux from CHO cells expressing the voltage-gated potassium (K_v) channel K_v1.3 (IC₅₀= 3.9 µM). Nalanthalide depolarizes T cellsin vitrowith an EC₅₀value of 500 nM. It also inhibits HIV-1 integrase activity with IC₅₀values of 10 and 25 µM in coupled and strand transfer assays, respectively.²

1.Goetz, M.A., Zink, D.L., Dezeny, G., et al.Diterpenoid pyrones, novel blockers of the voltage-gated potassium channel Kv1.3 from fungal fermentationsTetrahedron Lett.42(7)1255-1257(2001) 2.Singh, S.B., Jayasuriya, H., Dewey, R., et al.Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolitesJ. Ind. Microbiol. Biotechnol.30(12)721-731(2003)