GSK-A1 是一种选择性 III 型磷脂酰肌醇 4-激酶 PI4KA (PI4KIIIα) 抑制剂，pIC50 为 8.5-9.8。
货号:ajcx25530
CAS:1416334-69-4
分子式:C29H27FN6O4S
分子量：574.6
溶解度:DMSO: 2 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GSK-A1 is an inhibitor of phosphatidylinositol 4-kinase IIIα (PI4KIIIα; IC₅₀= 3.16 nM).¹It is selective for PI4KIIIα over PI4KIIIβ, PI3Kα, PI3Kβ, and PI3Kδ (IC₅₀s = >50 nM) but also inhibits PI3Kγ (IC₅₀= 15.8 nM). GSK-A1 decreases the levels of phosphatidylinositol 4-phosphate (PtdIns-(4)-P₁) but not PtdIns-(4,5)-P₂in HEK293 cells expressing the angiotensin II type 1 (AT₁) receptor (IC₅₀= 3 nM). GSK-A1 inhibits hepatitis C virus (HCV) genotype 1a and 1b replication.

1.Bojjireddy, N., Botyanszki, J., Hammond, G., et al.Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levelsJ. Biol. Chem.289(9)6120-6132(2014)