An inhibitor of caspase-1, -4, -5, and -11
货号:ajcx26338
CAS:N/A
分子式:C26H37ClN4O8 • XCF3COOH
分子量：569
溶解度:DMSO: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Ac-FLTD-CMK is an inhibitor of caspase-1, -4, -5, and -11.¹It inhibits caspase-1, -4, and -5 (IC₅₀s = 0.0467, 1.49, and 0.329, respectively, for the recombinant human enzymes) and cleavage of gasdermin D (GSDMD), an effector involved in pyroptosis and NETosis, by mouse caspase-11 when used at a concentration of 10 µM. Ac-FLTD-CMK (10 µM) inhibits LPS- and ATP- or LPS- and nigericin-induced pyroptosis and IL-1β release in mouse bone marrow-derived macrophages (BMDMs).

1.Yang, J., Liu, Z., Wang, C., et al.Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitorProc. Natl. Acad. Sci. USA115(26)6792-6797(2018)