| 规格: | 98% |
| 分子量: | 729.7 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
Background:
Ac-IETD-AFC is a fluorogenic substrate that can be cleaved by caspase-8 and related enzymes that recognize the amino acid sequence IETD, including caspase-3 processing enzyme, caspase-10, and granzyme B.1Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.
1.Reszka, P., Schulz, R., Methling, K., et al.Synthesis, enzymatic evaluation, and docking studies of fluorogenic caspase 8 tetrapeptide substratesChemMedChem5(1)103-117(2010)
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