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Amphotericin B methyl ester
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amphotericin B methyl ester图片
规格:98%
分子量:938.11
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
Amphotericin B methyl ester 是多烯类抗生素 Amphotericin B (A634250) 的甲酯衍生物。Amphotericin B methyl ester 是胆固醇结合物,具有显著的抗真菌活性。Amphotericin B methyl ester 干扰 HIV-1 颗粒的产生,抑制 HIV-1 的复制。
货号:ajcx29110
CAS:36148-89-7
分子式:C48H75NO17
分子量:938.11
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Amphotericin B methyl ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester disrupts HIV-1 particle production and potently inhibits HIV-1 replication[1][2].

Amphotericin B methyl ester inhibits HIV-1 particle production with no significant effect on Gag binding to the plasma membrane, Gag association with lipid rafts, or Gag multimerization[1].


[1]. Waheed AA, et al. Inhibition of human immunodeficiency virus type 1 assembly and release by the cholesterol-binding compound amphotericin B methyl ester: evidence for Vpu dependence. J Virol. 2008 Oct;82(19):9776-81. [2]. Keim GR, et al. Comparative toxicological studies of amphotericin B methyl ester and amphotericin B in mice, rats, and dogs. ntimicrob Agents Chemother. 1976 Oct;10(4):687-90.