SrcInhibitor3是一种有效的、口服活性的c末端Src激酶(CSK)，在CSKHTRF和Caliper实验中IC50值分别为低于3nM和4nM。SrcInhibitor3具有增强T细胞受体信号转导诱导的T细胞增殖的能力。
货号:ajcx31504
CAS:2380027-49-4
分子式:C34H32ClFN8O4
分子量：671.12
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Src Inhibitor 3 is a potent, orally active c-terminal Src kinase (CSK) with IC50 values below 3 nM and 4 nM in CSK HTRF and Caliper assay, respectively. Src Inhibitor 3 shows the ability to increase T cell proliferation induced by T cell receptor signaling[1].

Src Inhibitor 3 reduces inhibitory LCK phosphorylation in vivo upon oral dosing and shows the ability to enhance T cell activation in response to antigen stimulation[1].

[1]. O'Malley DP, et al. Discovery of Pyridazinone and Pyrazolo[1,5-a]pyridine Inhibitors of C-Terminal Src Kinase. ACS Med Chem Lett. 2019 Sep 25;10(10):1486-1491.