Palbociclib-propargyl是一种PROTAC靶蛋白CDK6的配体，可通过PEGlinker与CRBN配体结合，组成PROTACCP-10。CP-10可降解CDK6，DC50值为2.1nM。
货号:ajcx31692
CAS:2366269-23-8
分子式:C27H31N7O2
分子量：485.58
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1].

[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582.