PROTACARDegrader-4包含cIAP1配体结合基团，linker和雄激素受体(AR)配体结合基团。基于cIAP1的降解剂也被称为SNIPER。
货号:ajcx31856
CAS:N/A
分子式:C45H68F3N3O11
分子量：884.03
溶解度:DMSO: 200 mg/mL (226.24 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PROTAC AR Degrader-4 comprises a cIAP1 ligand binding group, a linker and an androgen receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].

Specific and Nongenetic IAPs-dependent Protein Erasers (SNIPERs) are bifunctional compounds which are designed by conjugating an IAPs-recognition structure with a target protein-recognition structure. Targeting proteins for degradation involves three steps. 1, its two recognition structures allow SNIPER to form a complex linking IAPs, which have E3 ligase activity, with the target protein. 2, the target protein is polyubiquitinated by IAPs. 3, the polyubiquitinated protein is degraded by proteasome.

[1]. Itoh Y, et al. Design, synthesis and biological evaluation of nuclear receptor-degradation inducers. Bioorg Med Chem. 2011 Nov 15;19(22):6768-78.