N-Boc-PEG4-bromide是一种PROTAC连接桥，属于PEG类和Alkyl/ether类。N-Boc-PEG4-bromide可用于合成一系列PROTAC分子。N-Boc-PEG4-bromide是一种可降解(cleavable)的ADC连接桥，用于抗体药物结合物(ADCs)的合成。
货号:ajcx32116
CAS:1076199-21-7
分子式:C13H26BrNO5
分子量：356.25
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N-Boc-PEG4-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG4-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[1]. Jan Anderl, et al. Amatoxin-Conjugates with Improved Linkers. US20130259880A1