Ecamsule disodium 一种广谱 UVA 防晒剂，可用于防晒产品。Ecamsule disodium 可减少由太阳辐射引起的生物损害，例如嘧啶二聚体的形成，p53 蛋白的积累或胶原酶 2 的表达。
货号:ajcx32534
CAS:90458-75-6
分子式:C28H32Na2O8S2
分子量：606.66
溶解度:DMSO : 50 mg/mL (82.42 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression[1][2].

Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm[1].Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 µM) treatment. In the fibroblasts, Ecamsule counteractes UV and AAPH induced ROS-formation. In addition, basal ROS levels are reduced. The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 µM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%. Ecamsule increases the viability at the highest applied concentration of 1600 µM in the AAPH-treated cells[1].

参考文献:
[1]. Stefanie Hofer, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244.
[2]. Vincent A DeLeo, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103.