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Ecamsule disodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ecamsule disodium图片
包装:500mg
规格:98%
市场价:445元
分子量:606.66

产品介绍
Ecamsule disodium 一种广谱 UVA 防晒剂,可用于防晒产品。Ecamsule disodium 可减少由太阳辐射引起的生物损害,例如嘧啶二聚体的形成,p53 蛋白的积累或胶原酶 2 的表达。
货号:ajcx32534
CAS:90458-75-6
分子式:C28H32Na2O8S2
分子量:606.66
溶解度:DMSO : 50 mg/mL (82.42 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression[1][2].

Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm[1].Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 µM) treatment. In the fibroblasts, Ecamsule counteractes UV and AAPH induced ROS-formation. In addition, basal ROS levels are reduced. The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 µM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%. Ecamsule increases the viability at the highest applied concentration of 1600 µM in the AAPH-treated cells[1].


参考文献:
[1]. Stefanie Hofer, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244.
[2]. Vincent A DeLeo, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103.