Benproperine phosphate 是一种具有口服活性的，有效的肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。Benproperine phosphate 通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。Benproperine phosphate 有潜力用于止咳，并可以抑制癌细胞迁移和肿瘤转移。
货号:ajcx32538
CAS:19428-14-9
分子式:C21H30NO5P
分子量：407.44
溶解度:DMSO : 250 mg/mL (613.59 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis[1].

Benproperine phosphate (20-120 µM; for 24?hours) inhibits cell viability in a dose-dependent manner[1]. Benproperine phosphate (10 µM; for 24?hours) significantly inhibits the migration of various types of cancer cells and inhibits the migration and invasion of DLD-1, AsPC-1 cells with IC50 values of 1-2?µM. Benproperine phosphate (10 µM; for 24?hours) does not affect cortactin-rich lamellipodium in MCF-10A cells[1].

Benproperine phosphate (50, 100mg/kg; oral gavage; 5?days per week for 4?weeks) inhibits primary pancreatic tumor growth[1]. Benproperine phosphate shows a marked decrease in the lung metastasis of AsPC-1 cells (56.1% inhibition) in mouse. Benproperine phosphate significantly suppressed the liver metastasis of HCT-116 cells by 78.9% and DLD-1 cells by 78.2%[1].

参考文献:
[1]. Yae Jin Yoon, et al. Benproperine, an ARPC2 inhibitor, suppresses cancer cell migration and tumor metastasis. Biochem Pharmacol. 2019 May;163:46-59.