Manzamine A hydrochloride 是 manzamine 生物碱的成员，是一种有效的，具有口服活性的 GSK-3β 抑制剂 (IC50=10.2 μM)。Manzamine A hydrochloride 通过靶向病毒基因 ICP0 显示出针对 HSV-1 的强效活性。Manzamine A hydrochloride 靶向液泡 ATP 酶 (vacuolar ATPases
货号:ajcx32896
CAS:104264-80-4
分子式:C36H45ClN4O
分子量：585.22
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Manzamine A hydrochloride, a member of the manzamine alkaloids, is a potent, orally active GSK-3β inhibitor (IC50=10.2 μM). Manzamine A hydrochloride shows potent activity against HSV-1 via targeting the viral gene ICP0. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities[1][2][3].

[1]. Hamann M, et al. Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease. J Nat Prod. 2007;70(9):1397-1405.
[2]. Winkler JD, et al. Antimalarial activity of a new family of analogues of manzamine A. Org Lett. 2006;8(12):2591-2594.
[3]. Kallifatidis G, et al. The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells [published correction appears in Mar Drugs. 2014;12(4):2305-7]. Mar Drugs. 2013;11(9):3500-3516. Published 2013 Sep 17.