KBU2046 是一种具有口服活性的，体外细胞运动和侵袭的高选择性抑制剂。KBU2046 结合伴侣异源复合物，选择性地改变调节运动性的侣伴蛋白的结合，并且缺乏经典HSP90抑制剂的所有标志。KBU2046 抑制癌症转移并延长寿命。
货号:ajcx33090
CAS:1143863-69-7
分子式:C15H11FO2
分子量：242.25
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

KBU2046 is an oral, highly selective inhibitor of cell motility and cell invasion in vitro. KBU2046 binds chaperone heterocomplexes, selectively alters binding of client proteins that regulate motility, and lacks all of the hallmarks of classical HSP90 inhibitors. KBU2046 inhibits cancer metastasis and prolongs life[1].

[1]. Xu L, et al. Precision therapeutic targeting of human cancer cell motility. Nat Commun. 2018 Jun 22;9(1):2454.