Redaporfin (LUZ11) 是一种有效的光敏剂，具有直接的抗肿瘤作用，以及对恶性病变的间接免疫依赖性破坏作用。
货号:ajcx33436
CAS:1224104-08-8
分子式:C48H38F8N8O8S4
分子量：1135.11
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Redaporfin (LUZ11) acts as a potent photosensitizer. Redaporfin causes direct antineoplastic effects as well as indirect immune‐dependent destruction of malignant lesions[1].

The combination photodynamic therapy (PDT) with Redaporfin (5μM) induces a reduction in the abundance of several Golgi apparatus (GA) proteins such as Golgi brefeldin A-resistant guanine nucleotide exchange factor 1 (GBF1), golgin subfamily A member 2 (GOLGA2), and galactosyltransferase 1 (GALT1), as well as that of two ER proteins, eukaryotic translation initiation factor 2-alpha (eIF2α) kinase 3 (EIF2AK3) and protein disulfide-isomerase A3 (PDIA3). In contrast, there is no major decrease in mitochondrial import receptor subunit TOM20 homolog (TOMM20) or in the cytoskeleton protein β-actin[1].

[1]. LÍgia C Gomes-da-Silva, et al. Photodynamic therapy with redaporfin targets the endoplasmic reticulum and Golgi apparatus. EMBO J. 2018 Jul 2;37(13):e98354.