WEE1-IN-3 是一种有效的 Wee1 激酶抑制剂，其 IC50<10 nm。wee1-in-3 具有抗癌活性。
货号:ajcx33744
CAS:2272976-28-8
分子式:C28H31N7O2
分子量：497.59
溶解度:DMSO : 250 mg/mL (502.42 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC50 of<10 nM. WEE1-IN-3 has anticancer activities[1].

WEE1-IN-3 (example 1) inhibits cancer cell growth with IC50 values of 100-1000 nM and<100 nM for SW480 cells and H23 cells, respectively[1].WEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ?Να repair before mitotic entry. Normal cells repair damaged DNA during GI arrest. Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. WEE1 is overexpressed in various cancer types[1].

[1]. Peter Qinhua HUANG, et al. 1, 2 - dihydro- 3h- pyrazolo [3, 4 - d] pyrimidin -3 - one analogs. WO2019028008A1.