Aureobasidin A (Basifungin) 是一种环状肽、是抗真菌的抗生素。Aureobasidin A (Basifungin) 是肌醇磷酸化神经酰胺合成酶 AUR1 的抑制剂。
货号:ajcx34542
CAS:127785-64-2
分子式:C60H92N8O11
分子量：1101.42
溶解度:DMSO : 100 mg/mL (90.79 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Aureobasidin A (Basifungin), a cyclic depsipetide, is an antifungal antibiotic. Aureobasidin A (Basifungin) A is an inhibitor of the inositolphosphorylceramide synthase AUR1[1][2].

Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides[2].

[1]. K Ikai, et al. Structure of aureobasidin A. J Antibiot (Tokyo). 1991 Sep;44(9):925-33.
[2]. Vanessa Cerantola, et al. Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides. Mol Microbiol. 2009 Mar;71(6):1523-37.
[3]. K Kino, et al. Aureobasidin A, an antifungal cyclic depsipeptide antibiotic, is a substrate for both human MDR1 and MDR2/P-glycoproteins. FEBS Lett. 1996 Dec 9;399(1-2):29-32.