CPT-157633 是一种二氟膦酰基甲基苯丙氨酸衍生物，是 PTP1B 抑制剂。 CPT-157633 可防止酗酒引起的葡萄糖耐受不良。
货号:ajcx34646
CAS:888213-72-7
分子式:C12H16BrF2N2O6PS
分子量：465.2
溶解度:DMSO : 200 mg/mL (429.92 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CPT-157633, a difluoro-phosphonomethyl phenylalanine derivative, and is a PTP1B inhibitor. CPT-157633 prevents binge drinking-induced glucose intolerance[1].

CPT-157633 (0.2 µg/day; intracerebroventricular infusion) alleviates the hypothalamic inflammation and glucose intolerance induced by binge drinking in rats[1].

[1]. Lindtner C, et, al. Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action. Sci Transl Med. 2013 Jan 30;5(170):170ra14.