MRTX1133 是一种高选择性、首创的 KRAS G12D 抑制剂。MRTX1133 靶向处于活性和非活性状态的 KRAS G12D 蛋白。MRTX1133 选择性抑制 KRAS G12D 突变体肿瘤细胞，但不抑制 KRAS 野生型。
货号:ajcx34978
CAS:N/A
分子式:C34H33F3N6O4
分子量：646.66
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MRTX1133 is a highly selective, first-in-class inhibitor of KRAS G12D. MRTX1133 targets the KRAS G12D protein in both active and inactive states. MRTX1133 selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tumor cells[1][2].

MRTX1133 demonstrates dose-dependent inhibition of the KRAS pathway tumor regression in G12D mutant tumor models[2].

[1]. Xiaolun Wang, et al.Kras g12d inhibitors.WO2021041671A1.
[2]. KRAS G12D Inhibitor: MRTX1133. [(accessed on 22 April 2021)];2021 Available online.