FNC-TP 是 FNC 的细胞内活性形式。FNC 是一种有效的核苷逆转录酶抑制剂 (NRTI)，对 HIV、HBV 和 HCV 具有抗病毒活性。
货号:ajcx35884
CAS:2457357-99-0
分子式:C9H14FN6O13P3
分子量：526.16
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

FNC-TP is the intracellular active form of FNC. FNC is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV[1].

FNC (0.1-10 nM; 24-240 h) is found mainly to accumulate in these HIV-1 target cells, and the retention of FNC-TP is 2-4 times higher than in other types of cells[1].

FNC (1-6 mg/kg; a single p.o.) could enter rhesus macaque PBMCs and form the active nucleoside triphosphate FNC-TP[1].

[1]. Sun L, et, al. Mechanistic Insight into Antiretroviral Potency of 2’-Deoxy-2’-β-fluoro-4’-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention. J Med Chem. 2020 Aug 13;63(15):8554-8566.