Bromo-PEG2-C2-azide 是一种不可降解的 ADC linker，用于合成抗体偶联药物 (ADC)。Bromo-PEG2-C2-azide 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。
货号:ajcx36014
CAS:530151-56-5
分子式:C6H12BrN3O2
分子量：238.08
溶解度:DMSO : 100 mg/mL (420.03 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Bromo-PEG2-C2-azide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bromo-PEG2-C2-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Yong Zu Kim, et al. Antibody-drug conjugates comprising branched linkers and methods related thereto. WO2017089895A1.