RdRP-IN-2 是一种依赖于 RNA 的 RNA 聚合酶 (RdRp) 抑制剂。 RdRP-IN-2 显着抑制 SARS-CoV-2 RdRp，IC50 为 41.2 µM。RdRP-IN-2 还抑制猫冠状病毒 (FIPV) 复制。
货号:ajcx36354
CAS:N/A
分子式:C33H30N2O5S
分子量：566.67
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RdRP-IN-2 is a RNA dependent RNA polymerase (RdRp) inhibitor. RdRP-IN-2 significantly inhibits SARS-CoV-2 RdRp with an IC50 of 41.2 µM.RdRP-IN-2 also inhibits Feline coronavirus (FIPV) replication[1].

RdRP-IN-2 (Compound 17) completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV). RdRP-IN-2 is not cytotoxic for Vero and CRFK cells[1].RdRP-IN-2 (Compound 17) shows anti-SARS-CoV-2 activities with an EC50 value of 527.3 nM in Vero cells[1].

[1]. Milan Dejmek, et al. Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication. Viruses. 2021 Aug 11;13(8):1585.