NVS-ZP7-4是一种锌转运体SLC39A7(ZIP7)的抑制剂，也是第一个报道的能探测内质网锌水平影响的化学分子，研究ZIP7作为Notch通路中的一种新的药物节点。
货号:ajcx13372
CAS:2349367-89-9
分子式:C28H28FN5OS
分子量：501.62
溶解度:DMSO : ≥ 125 mg/mL (249.19 mM);H2O :< 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.

NVS-ZP7-4 increases ER zinc levels, suggesting functional modulation of ZIP7[1].

[1]. Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15(2):179-188.