DDD107498 succinate (DDD-498 succinate) 是一种有效、可口服的抗疟疾 (antimalarial) 剂，能够抑制寄生虫生命周期的多个阶段，对 P. falciparum 3D7 的 EC50 值为 1 nM。DDD107498 succinate (DDD-498 succinate) 通过靶作用于 eEF2/CaMKIII 来抑制蛋白合成，对 WT-PfeEF2 的 EC50 值为 2 nM。
货号:ajcx13844
CAS:2444781-71-7
分子式:C31H37FN4O6
分子量：580.65
溶解度:DMSO: 135 mg/mL (232.50 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DDD107498 succinate (DDD-498 succinate) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. DDD107498 succinate inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2[1]. EC50: 1 nM (3D7 parasites), 2 nM (WT-PfeEF2)[1]

DDD107498 exhibits an ED90 of 0.57 mg/kg after a single oral dose in mice infected with the rodent parasite P. berghei[1].

[1]. BaragaÑa B, et al. A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. 2015 Jun 18;522(7556):315-20.