The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids.
货号:ajcx18916
CAS:N/A
分子式:C47H82O22P4•4Na
分子量：1215
溶解度:CHCl3:CH3OH:H2O (3:2:1): 10 mg/ml,PBS (pH 7.2): Freely soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and Akts are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific PLC. Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see also references and .